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Finally, both polyphenols and exercise contribute to improved insulin sensitivity and glucose metabolism

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Neuroprotective Potential : In experimental models of ischemia and neuronal stress, TREK-1 modulation has been linked with altered neuronal survival outcomes

Moreover, FosB expression was increased in anorexigenic proopiomelanocortin neurons within the hypothalamic arcuate nucleus, which reduce feeding and have been implicated in promoting sympathetic excitation

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